Circadian Rhythms and the Toxicity of Central Nervous System Drugs.
Abstract
Twenth-four hour LD50 rhythms were determined for d1-amphetamine in isolated and aggregated mice. In both cases peak toxicity occurred between the 4th and 7th hour of the twelve hour dark period. Peak toxicity for d1-amphetamine in isolated groups was significantly greater during the month of January when compared to the month of June of the same year. In additional studies on the effects of amphetamine in sublethal doses, on twenty-four hour rhythms of whole brain amines and blood glucose levels in the mice, the blood glucose level for control animals showed a diurnal rhythm. In another experiment, male Sprague Dwaley rats injected with 2 mg/kg of ethyl alcohol and analyzed one hour later at eight different times of the day showed diurnal rhythms for the urine and specific tissues.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 09, 1976
- Accession Number
- ADA033111
Entities
People
- Karam F. A. Soliman