Localization of 99m sub T c Diphosphonate in Acutely Injured Muscle: Relationship to Muscle Calcium Deposition.

Abstract

In rats with experimental ischemic myopathy there was a significant correlation (r=0.778, p<0.001) between muscle uptake of TC(99m) diphosphonate (EHDP) and tissue calcium concentration. In addition, the accumulation of both calcium and Tc(99m) EHDP in acutely injured muscles was further increased in rats with vitamin D-induced hypercalcemia. Results suggest that the uptake of 99mTc EHDP in acutely damaged skeletal muscle is directly related to the deposition of calcium salts within the injured muscle fibers.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1976
Accession Number
ADA033232

Entities

People

  • B. A. Siegel
  • E. C. Derrer
  • W. K. Engel

Organizations

  • Armed Forces Radiobiology Research Institute

Tags

DTIC Thesaurus Topics

  • Animal Structures
  • Blood
  • Blood Vessels
  • Cells
  • Cellular Structures
  • Diseases And Disorders
  • Electron Microscopy
  • Mitochondria
  • Muscle Cells
  • Muscle Fibers
  • Muscles
  • Nuclear Medicine
  • Organelles
  • Radiopharmaceuticals
  • Skeletal Muscle
  • Smooth Muscle
  • Tissues

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology
  • Cellular and Molecular Pathways of Apoptosis.
  • Trauma Surgery or Emergency Medicine.