Effect of Leukocytic Endogenous Mediators (LEM) on the Secretory Response of the Endocrine Pancreas.

Abstract

In addition to previous reports of metabolic alterations, these data show that one hour after the intraperitoneal injection of LEM, plasma insulin and glucagon concentrations are elevated; at 2 hours the preceding hormonal alterations are manifested by hepatic metabolic alterations. There is a 30 percent increase in cyclic adenosine monophosphate (AMP), glycogen concentrations are depressed, and the concentration of C(14) labeled non-metabolizable amino acid analogs is elevated. The plasma hormone concentrations continue to increase and reach maximum levels by 5 hours, declining to basal by 24 hours. The plasma insulin and glucagon respones to LEM can explain the observed increases in hepatic cyclic-AMP, uptake of C(14)-labeled amino acid analogs, and glycogenolysis as well as the relative hypoglycemia.

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Document Details

Document Type
Technical Report
Publication Date
Apr 26, 1976
Accession Number
ADA033382

Entities

People

  • Carol A. Mapes
  • David T. George
  • Fred B. Abeles
  • Philip Z. Sobocinski
  • Terry V. Zenser

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Animals
  • Biomedical Research
  • Blood
  • Carbohydrate Metabolism
  • Cells
  • Glucose Metabolism Disorders
  • Hormones
  • Infection
  • Insulin
  • Ketones
  • Laboratory Animals
  • Leukocytes
  • Linear Regression Analysis
  • Metabolism
  • Regression Analysis
  • Statistical Analysis

Readers

  • Cardiovascular Physiology
  • Molecular and Cellular Biochemistry