Ethanol-Induced Depletion of Cerebellar Guanosine 3',5'-Cyclic Monophosphate Levels.

Abstract

Single doses of ethanol induce a severe depletion (95 percent) of cerebellar guanosine 3-5-cyclic monophosphate (C-GMP) levels within 1 hour after administration. The degree of this depletion is a function of the amount of ethanol in the blood. Interactions between ethanol and C-GMP may account for some of the intoxicating properties of ethanol. The results of this study provide further information on the development and exploration of models for chronic insults to the brain, such as long-term exposure to toxic chemicals and ionizing and nonionizing radiation. (Author)

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1976
Accession Number
ADA033403

Entities

People

  • George N. Catravas
  • J. D. Redos
  • W. A. Hunt

Organizations

  • Armed Forces Radiobiology Research Institute

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Adenosine
  • Alcoholic Beverages
  • Alkynes
  • Amino Acids
  • Atropine
  • Brain
  • Brain Stem
  • Central Nervous System
  • Cerebellum
  • Cerebral Cortex
  • Digestive System Processes
  • Glutamates
  • Guanosine
  • Nervous System
  • Neurosciences
  • Nucleotides
  • Radiation

Fields of Study

  • Medicine

Readers

  • Agricultural Chemistry/Soil Science
  • Child and Adolescent Substance Abuse Science in Autism Spectrum Disorders.
  • Nuclear and Radiation Engineering.