Cerebellar cGMP Levels Reduced by Narcotic and Hypnotic Drugs: Correlation with Drug-Induced Ataxia.

Abstract

Maintenance of normal coordination and smooth motor activity requires an intact Purkinje cell system in the cerebellum. Acute adminstration of morphine or pentobarbital results in a reduction in the cGMP pool of cerebellar Purkinje cells that is both dose and time dependent. The induction of ataxia by these drugs correlates with their ability to depress cerebellar cGMP levles. Animals tolerant to morphine show neither the cGMP reduction nor ataxia.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1976
Accession Number
ADA033406

Entities

People

  • George N. Catravas
  • J. B. Katz

Organizations

  • Armed Forces Radiobiology Research Institute

Tags

DTIC Thesaurus Topics

  • Alkenes
  • Brain
  • Central Nervous System
  • Central Nervous System Stimulants
  • Cerebellum
  • Climbing
  • Death
  • Firing Rate
  • Human Behavior
  • Medical Engineering
  • Morphine
  • Nervous System
  • Nucleotides
  • Security
  • Skeletal Muscle

Fields of Study

  • Biology
  • Psychology

Readers

  • Brain and Cognitive Science; Experimental Psychology; Cognitive Neuroscience
  • Cardiovascular Physiology
  • Parasitology and Pharmacology of Malaria.