Investigations into the Immunological Basis of Eosinophilia Induced by Experimental Schistosomiasis.
Abstract
Antigen-specific granulomas about Schistosoma mansoni eggs, in normal or presensitized mouse lungs, contained more than 20% eosinophil leukocytes, in addition to macrophages, epithelioid cells, and lymphocytes. This was accompanied by blood eosinophilia. Delayed reactions to footpad tests with soluble egg antigen(s) showed histologic eosinophilia parallel with that in the pulmonary granulomas and blood. In sensitized guinea pigs, the inflammatory infiltration elicited by cercarial penetration of the skin, showed the characteristics of cutaneous basophil hypersensitivity while egg granulomas in the liver, like the murine egg granulomas, contained mononuclear cells and eosionphils. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1974
- Accession Number
- ADA033504
Entities
People
- Gene I. Higashi
Organizations
- Yale University