Unilateral Intracerebral Morphine Injections: Bilateral Bioelectric Response, Unilateral Tolerance.

Abstract

The anterior amygdala region of the brain was subjected to daily unilateral injections of either 2.7 or 9.0 micrograms of morphine sulfate. Initial administration produced epileptiform patterns at the injection site and at the homotopic site in the contralateral hemisphere. While tolerance developed at the initial injection site after repeated administration, the contralateral site retained normal sensitivity to the drug.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1976
Accession Number
ADA033510

Entities

People

  • George N. Catravas
  • H. Teitelbaum
  • J. C. Blosser

Organizations

  • Armed Forces Radiobiology Research Institute

Tags

DTIC Thesaurus Topics

  • Assembly
  • Base Lines
  • Brain
  • Brain Diseases
  • Central Nervous System Diseases
  • Diseases And Disorders
  • Electrophysiological Phenomena
  • Epilepsy
  • Hemispheres
  • Morphine
  • Nervous System Diseases
  • Opioids
  • Sensitivity

Fields of Study

  • Biology
  • Psychology

Readers

  • Neuroscience
  • Toxicology/Environmental Toxicology