Suppression by 1,3-Butanediol of the Ethanol Withdrawal Syndrome in Rats.

Abstract

1-3-Butanediol (BD) was tested for its ability to suppress an ethanol withdrawal syndrome. Male Sprague-Dawley rats were rendered physically dependent upon ethanol by intragastric administration of 9-15 g/kg of ethanol per day over a 4-day period. A nonintoxicating dose of BD of 4 g/kg, p.o., administered after elimination of ethanol from the blood was effective against the tremulous and convulsive components in all animals for 1-5 hours. This period of time coincided with the time of maximum severity of the withdrawal syndrome as seen in the control animals. These results suggest that BD may be useful in the treatment of the ethanol withdrawal syndrome in man. (Author)

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1976
Accession Number
ADA033511

Entities

People

  • C. Piantadosi
  • E. Majchrowicz
  • W. A. Hunt

Organizations

  • Armed Forces Radiobiology Research Institute

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Alcohols
  • Aldehydes
  • Animals
  • Cirrhosis
  • Elimination
  • Gas Chromatography
  • Intoxication
  • Malnutrition
  • Nervous System
  • Neurobehavioral Manifestations
  • Neuropathy
  • Nutrition
  • Rhesus Monkeys
  • Seizures
  • Side Effects
  • Substance-Related Disorders

Fields of Study

  • Medicine

Readers

  • Polymer Science and Technology
  • Toxicology/Environmental Toxicology