Cardiac Output and Vascular Response to Trauma
Abstract
The physiological responses to trauma, shock, or sepsis which lead to recovery have been measured and documented to delineate the situations in which death occurs for lack of adequate responses. The relationship of increased circulatory demands to respiratory and metabolic abnormalities encountered under these conditions was investigated during this period. The purpose of this report is to review in separate sections the clinical syndrome of altered respiratory and circulatory functions, the pulmonary morphological abnormalities, changes in pulmonary metabolism, and the evidence for a circulating peptide as the principal etiological agent. This agent which probably is a small peptide initiates a sequence of pathological events in the lung. An early interstitial pneumonitis (Phase I) is followed, if unchecked, by bronchopneumonia (Phase II). Finally, based on these findings the value of certain therapeutic measures for the prevention or treatment of this dangerous complication are presented.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 23, 1976
- Accession Number
- ADA033570
Entities
People
- George H. Clowes Jr.
Organizations
- Harvard Medical School