Effect of Harvest Time of Rickettsia rickettsii from Duck Embryo Cell Cultures on Rocky Mountain Spotted Fever Infection in the Rhesus Monkey.

Abstract

This study was undertaken to determine the optimum harvest time for infected duck embryo cell (DEC) cultures to yield the highest rickettsial titers and greatest infectivity for rhesus monkeys. A consistently reproducible Rocky Mountain spotted fever-infected monkey model for pathogenesis studies and testing vaccine is produced when the inoculum given intravenously contains >=1000000 chick embryo median lethal dose organisms. This is optimally attained with day-4 DEC culture harvest material. (Author)

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Document Details

Document Type
Technical Report
Publication Date
Dec 15, 1976
Accession Number
ADA033796

Entities

People

  • Duane E. Hilmas
  • Gerald L Ruch

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animals
  • Cells
  • Culture Techniques
  • Diseases And Disorders
  • Incubation
  • Infection
  • Infectious Diseases
  • Laboratory Animals
  • Lethal Dosage
  • Materials
  • Mountains
  • Pathogenesis
  • Rhesus Monkeys
  • Rocky Mountains
  • Rodents
  • Tickborne Diseases
  • Wound Infections

Readers

  • Mathematics or Statistics
  • Neurodegenerative Parkinson's Disease and Rickettsial Disease handbook, including the data level of dopamine, BC, neurons, and PD.
  • Virology (or Medical Virology).

Technology Areas

  • Biotechnology