'In Vitro' Inhibition of Microsomal Calcium Atpase from Eggshell Gland of Mallard Duck.

Abstract

The results of this study have demonstrated the inhibition of Ca ATPase by DDT in an in vitro microsomal test system. Furthermore, this inhibition has been established to be competitive in nature. The results are similar to those of other investigators who showed Ca ATPase inhibition by DDE in shell gland homogenate. Previous studies have shown DDT-induced eggshell thinning to be due to decreased calcium content of eggshells. Since calcium ATPase has been shown to be associated with calcium transport in eggshell gland, the inhibition of this enzyme in vitro offers a possible explanation for DDT-induced eggshell thinning.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1976
Accession Number
ADA034728

Entities

People

  • David E. Hinton
  • Gerald J. Kolaja

Tags

DTIC Thesaurus Topics

  • Birds
  • Inhibition
  • Transport Ships

Readers

  • Aquatic Ecology
  • Molecular and Cellular Biochemistry