A Deficiency of Hematopoietic Stem Cells in Steel Mice.

Abstract

Steel-Dickie mice which have a genetic defect were selected for a model to determine some of the interaction of ionizing radiation with bone marrow cells. Therefore, population sizes of high self-renewal potential stem cells, i.e., colony forming units and low self-renewal potential stem cells, i.e., transient endogenous colony forming units in Steel mice and their normal congenic littermates were measured and compared. By correcting for differences in the seeding efficiency 'f', it was possible to demonstrate that Sl Sl(d) mice suffer a deficiency of both stem cell populations. It is concluded that the defective stromal tissue of the Sl(d) mouse does not support normal size stem cell populations.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1976
Accession Number
ADA034976

Entities

People

  • G. David Ledney
  • K. F. Mccarthy
  • R. G. Mitchell

Organizations

  • Armed Forces Radiobiology Research Institute

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Blood
  • Blood Cells
  • Body Weight
  • Bone Marrow
  • Bone Marrow Cells
  • Bones
  • Cells
  • Deficiencies
  • Efficiency
  • Erythropoiesis
  • Genotypes
  • Hematopoietic Cells
  • Ionizing Radiation
  • Lymphatic System
  • Radiation
  • Stem Cells

Readers

  • Immunology and Pathology
  • Molecular and genetic basis of cancer.

Technology Areas

  • Biotechnology