Spontaneous Reactivation of Acetylcholinesterase following Organophosphate Inhibition. III Studies with para-nitrophenyl Methylphenylphosphinate.

Abstract

Inhibition constants for the phosphinylation of eel acetylcholinesterase by para-nitrophenyl methylphenyl-phosphinate are reported, as are the constants for the subsequent spontaneous reactivation reaction. The data support the rationale that phosphinates are ideally suited for studies directed at advantageously perturbing the spontaneous reactivation process. (Author)

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1976
Accession Number
ADA035231

Entities

People

  • Claire N. Lieske
  • Donald K. Jewell
  • Gary L. Horton
  • James H. Clark
  • John R. Lowe

Tags

Communities of Interest

  • Biomedical
  • Weapons Technologies

DTIC Thesaurus Topics

  • Acetylcholinesterases
  • Amino Acids
  • Biochemistry
  • Chemical Reactions
  • Chemistry
  • Computer Programs
  • Equations
  • Health Services
  • Mass Spectra
  • Mass Spectroscopy
  • Materials
  • New York
  • Organophosphorus Compounds
  • Phosphorus
  • Poisoning
  • Rodents
  • Spectra

Fields of Study

  • Chemistry

Readers

  • Neurotoxicology
  • Theoretical Analysis.