Response of Influenza-Virus Infected Mice to Selected Doses of Ribavirin Administered Intraperitoneally or by Aerosol.
Abstract
Influenza virus-infected mice were given graded doses of ribavirin intraperitoneally (i.p.) and by aerosol to determine the relative efficacy of the two routes of administration. Percent survival, lung pathology (expressed as lesion scores) and titer of virus in the lungs were determined. The ED90 values (in terms of survival) were 9.9 and 47.9 mg/kg/day for aerosol and i.p. routes, respectively. Lung lesion scores and titers of virus were also lower after aerosol than i.p. therapy with identical doses.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 14, 1977
- Accession Number
- ADA035261
Entities
People
- E. L. Stephen
- J. S. Walker
- J. W. Dominik
- R. F. Berendt
Organizations
- United States Army Medical Research Institute of Infectious Diseases