Evaluation of Vascular Clearance as a Marker for Virulence of Alphaviruses: Disassociation of Rapid Clearance with Low Virulence of Venezuelan Encephalitis Virus Strains in Guinea Pigs.
Abstract
In the present study, using guinea pigs, six of six virulent strains of Venezuelan encephalitis virus (VEE) were cleared inefficiently, while three of six nonlethal or benign virus strains were cleared rapidly. However, three other guinea pigs-benign VEE strains cleared slowly, like lethal strains. The inability of one benign virus strain, which cleared slowly, to produce a high viremia was correlated with inefficient growth in primary viral replication sites. Thus, while the low virulence of certain alphavirus strains may depend primarily on rapid clearance (e.g., TC-83, VEE vaccine in the hamster), the low virulence of other alphaviruses may depend on factors other than vascular clearance.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 10, 1977
- Accession Number
- ADA035281
Entities
People
- Gregory B. Heisey
- Peter B. Jahrling
- Richard A. Hesse
Organizations
- United States Army Medical Research Institute of Infectious Diseases