Mutagen and Oncogen Study on N-Phenyl-Alpha-Naphthylamine

Abstract

A three tier test was organized into a matrix of assays employing microbial cells, mammalian cells in culture, and in vivo experiments in mice. N-phenyl-alpha-naphthylamine did not exhibit mutagenic activity in any of the assays. A weak positive response for unscheduled DNA synthesis (UDS) in WI-38 cells was noted at a single dose level of the compound. This effect was reproduced in a repeat test of UDS.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1976
Accession Number
ADA035476

Entities

People

  • Dale W. Matheson
  • David Brusick

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Air Force
  • Air Force Facilities
  • Amines
  • Amino Acids
  • Animals
  • Biomedical Research
  • Cell Physiological Processes
  • Cells
  • Contracts
  • Detection
  • Government Procurement
  • Governments
  • Medical Personnel
  • Microsomes
  • Plant Oils
  • Toxicity
  • United States

Fields of Study

  • Biology

Readers

  • Computer Science.
  • Toxicology/Environmental Toxicology

Technology Areas

  • Biotechnology