Annual Report.

Abstract

These studies suggest that previously held assumptions regarding protective effects of hypoxemia against oxygen toxicity are probably invalid. This is particularly true in the case of anoxic ventilation as indicated in the first set of studies which showed an increase in interstitial edema and exaggeration of changes in pulmonary capillary pressures as a consequence of relatively short periods of ventilation with FI)2 1.0 oxygen. The consequences of more profound anoxic perfusion are less dramatic but appear again to offer no protection from the extravasation of fluid through pulmonary capillaries as a consequence of ventilation with FIO2 oxygen. Slight differences were observed when the perfusion PaO2 was lowered below 15 mmHG and combined with a period of anoxic ventilation. These lungs showed less edema formation than those perfused with a PaO2 of 15 - 29 mmHg subjected to the same period of anoxic ventilation.

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Document Details

Document Type
Technical Report
Publication Date
Feb 07, 1977
Accession Number
ADA035699

Entities

People

  • Lazar J. Greenfield

Organizations

  • Virginia Commonwealth University School of Medicine

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  • Biomedical

DTIC Thesaurus Topics

  • Acute Respiratory Distress Syndrome
  • Arteries
  • Biomedical Research
  • Blood
  • Body Weight
  • Cardiovascular Diseases
  • Cardiovascular Physiological Phenomena
  • Cardiovascular System
  • Diseases And Disorders
  • Hemorrhagic Shock
  • Infection
  • Lung Diseases
  • Microvessels
  • Military Research
  • Perfusion
  • Security
  • Ventilation

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