Properties of Erythrocytes Which May Influence the Conversion of Profibrinolysin to Fibrinolysin,
Abstract
Evidence is presented that erythrocytes adsorb urokinase, a urinary activator of plasma profibrinolysin, and that in the adsorbed state urokinase not only remains active but is 'protected' from factors normally present in plasma. When washed red cells, devoid of components of the fibrinolytic system, are exposed to plasma they acquire simultaneously inhibitors to urokinase and an agent capable of lysing a fibrin clot. Evidence is presented that these acquired properties are the result of adsorption to the erythrocyte of factors present in plasma and that this adsorption is affected by the fibrinolytic status of the animal from which the plasma and erythrocytes are obtained. The significance of the erythrocyte in the development of in vivo fibrinolytic activity is discussed.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1959
- Accession Number
- ADA036238
Entities
People
- D. R. Celander
- M. Mason Guest
- S. N. Kolmen