Toxic Effects of S,2-Aminoethylisothiuronium Dibromide,

Abstract

The toxicity and patholgic effects of S,2-aminoethylisothiuronium dibromide (AET-DiBr), a radioprotectant compound, have been studied in rats. The compound is highly toxic to these rodents when given in acute doses either orally or intraperitoneally. The chronic toxicity and pathology of AET-DiBr has been examined by means of serial intraperitoneal injections. At low doses, large total amounts of the drug can be tolerated. The acute and chronic effects of sodium chloride, sodium bromide, sodium acetate, and sodium nitrate have been tested. Neither the anions nor the cation appears to contribute to the toxicity of isothiuronium salts.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1959
Accession Number
ADA036240

Entities

People

  • George S. Melville Jr.
  • Thomas P. Leffingwell

Tags

DTIC Thesaurus Topics

  • Alkali Metals
  • Chemical Compounds
  • Chlorides
  • Elements
  • Group 1 Elements
  • Metals
  • Pathology
  • Sodium
  • Sodium Compounds
  • Toxicity

Readers

  • Organic Chemistry
  • Toxicology/Environmental Toxicology