Immunology of Malaria.
Abstract
Clinical investigations were conducted to determine whether non-immune persons can be immunized against vivax or falciparum malaria after exposure to X-irradiated sporozoites of Plasmodium vivax or Plasmodium falciparum. Batches of Anopheles stephensi mosquitoes were infected with malaria and, 12 to 18 days later, they were irradiated with X-rays until they had received a dose of at least 12 Krads. The findings indicate that protection against malaria can be obtained by inoculation of human malaria sporozoites attenuated by X-irradiation. It is unclear at present whether the inoculation of larger number of sporozoites on one or two occasions might induce long-term protection against malaria. This question can be answered only when pure sporozoite preparations, free of mosquito tissue and contaminating microorganisms, become available for human evaluation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 12, 1976
- Accession Number
- ADA036341
Entities
People
- Karl H. Rieckmann