Topical Hazard Evaluation Program of Candidate Insect Repellent AI3-36540-a 1-(Cyclohexylcarbonyl)-2,6-Dimethylpiperidine.

Abstract

A hazard evaluation of AI3-36540-a was conducted using New Zealand White rabbits for skin and eye studies; Hartley guinea pigs for a skin sensitization study; and Sprague-Dawley, Wistar-derived rats for determination of acute oral toxicity. AI3-36540-a is a potential sensitizing chemical. Technical grade compound produced severe injury to the cornea and to the conjunctiva of the rabbit and may cause similar damage if it should accidentally enter the eye of man. Ethanol solutions of this compound caused a photochemical skin irritation reaction in rabbits and may prove to be phototoxic on the skin of man.

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Document Details

Document Type
Technical Report
Publication Date
Mar 11, 1977
Accession Number
ADA037078

Entities

People

  • Brenda J. Desena
  • Maurice H. Weeks

Organizations

  • United States Army Medical Command

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abrasion
  • Alcohols
  • Animals
  • Eye
  • Health Services
  • Hygiene
  • Insect Repellents
  • Irritation
  • Laboratory Animals
  • Lagomorphs
  • New Zealand
  • Pest Control
  • Physical Properties
  • Rodents
  • Test And Evaluation
  • Toxicity

Fields of Study

  • Medicine

Readers

  • Toxicology/Environmental Toxicology