Kinetics of Neutrophil-Releasing Activity of Post-Leukopheresis Plasma.
Abstract
Plasma obtained from leukopheresed rats (P.P.P.) may be used to increase granulocyte yields in donors when given prior to leukopheresis. In these studies it appears that (a) the effect of injection of P.P.P. is dose-related and is not an 'all or none' phenomenon, (b) the granulocytosis observed in the donor is related to the duration of pheresis for periods up to three hours, (c) the titer of neutrophil releasing activity is related to the duration of pheresis, (d) the granulocyte increments in the donor are proportional to the duration of pheresis, and (e) there is a good correlation between the donor post-pheresis granulocyte count, as well as the donor post-pheresis granulocyte increment to the neutrophil releasing activity of the plasma obtained from the donor. There is no relationship between the recipient pre-granulocyte count and the ability of the recipient to respond to injections of P.P.P., or the ability of groups of rats to respond to injections of P.P.P. on two successive days.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 1977
- Accession Number
- ADA037139
Entities
People
- Albert J. Roy