Influence of Altered Gaseous Environments on Lung Metabolism.
Abstract
Isolated lungs were perfused 1.5 hours with a medium of washed bovine red cells resuspended to a 15 percent hematocrit with Krebs-Henseleit bicarbonate buffer containing 5 gram percent albumin. Substrate concentrations were 6 millimolar glucose and 1 millimolar palmitate. Data from altered carbon dioxide tension experiments indicate that prior exposure to high carbon dioxide tension markedly alters the lung's ability to maintain synthesis of cellular constituents from glucose. In a second series of experiments acute effects of hyperoxia on lung metabolism were examined. Lactate production increased and pyruvate decreased. Data from a series of test of hypoxia on cyclic nucleotides indicate that hypoxia has a selective action on lung cAMP and nutritional stress potentiates a hypoxic-hypercapnia exposure drastically alters lung weight, glycolysis and lipid synthesis in the lung. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1976
- Accession Number
- ADA037977
Entities
People
- Rodney A. Rhoades
Organizations
- Pennsylvania State University