The Role of Inorganic Phosphate in Oxygen Transport.
Abstract
The studies examine the mechanisms causing anemia associated with massive transfusion, injury, and protein depletion. Following injury protein depletion occurs, with loss of inorganic phosphate. As inorganic phosphate modulates red cell glycolysis, it is basic to oxygen transport. The study suggests that during anemia, oxygen unloading is increased as 2,3 DPG levels increase. By assessing erythropoieting in conjunction with red cell oxygen unloading capabilities, we have presumptive evidence that the hypoxic stimulus which results in erythropoietin elevation which causes red cell production, is compensated for by 2-3 DPG elevation. The persistent reticulopenic anemia which follows injury and results in the need for blood transfusion, may be due to DPG compensation for hypoxia failure of erythropoietin production and persistent anemia. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 28, 1977
- Accession Number
- ADA038769
Entities
People
- George F. Sheldon
Organizations
- University of California, San Francisco