Physiological Disposition and Metabolism of H(3) Cocaine.

Abstract

This project deals in depth with the dispositional and metabolic aspects of H(3) cocaine in the rat, dog and the monkey in acute and chronic states with a view to assess the possible relationship and significance of these parameters to the acquired sensitivity (reverse tolerance) and systemic toxicity to cocaine in these species on chronic treatment. Various metabolites of cocaine observed in the brain of these experimental animals were also prepared and their disposition studied in the rat. Sensitive and specific methodologies for the estimation and identification of cocaine and its metabolites in biological materials were developed.

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Document Details

Document Type
Technical Report
Publication Date
Jan 31, 1977
Accession Number
ADA039031

Entities

People

  • Anand L. Misra
  • Salvatore J. Mule

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biological Sciences
  • Brain
  • Central Nervous System
  • Central Nervous System Stimulants
  • Chemical Synthesis
  • Chemistry
  • Drug Abuse
  • Free Radicals
  • Laboratory Animals
  • Medical Personnel
  • Nervous System
  • Organic Chemistry
  • Pharmacology
  • Seizures
  • Three Dimensional
  • Two Dimensional

Fields of Study

  • Biology
  • Psychology

Readers

  • Cardiovascular Physiology
  • Team-Based Human-Centered Cognitive Task Decision Making and Information Performance.