The Physiological Role of Red Cell 2,3 DPG in Oxygen Transport,
Abstract
The physiologic role of red cell 2,3 DPG has been studied in various situations. Healthy volunteers were studied after exposure to a simulated altitude of 4,500 meters. Hyperventilated, anemic baboons were studied to determine the effects of therapeutic transfusions of red cells with high 2,3 DPG and low affinity for oxygen and of red cells with low 2,3 DPG and high affinity for oxygen. The red cell 2,3 DPG level affects the in vivo P50 value which, in turn, affects erythropoietin production. In the baboon, the red cell 2,3 DPG level has been shown to increase oxygen delivery to tissue and decrease blood flow requirements to maintain oxygen consumption. In hyperventilated, anemic baboons, red cells with decreased 2,3 DPG and increased affinity for oxygen produced a significant increase in cerebral blood flow.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 25, 1973
- Accession Number
- ADA039082
Entities
People
- C. Robert Valeri