Laboratory-Acquired Rocky Mountain Spotted Fever: The Hazard of Aerosol Transmission.

Abstract

Nine patients with laboratory-acquired Rocky Mountain spotted fever (RMSF) were seen during the period 1971-1976. Investigation of each case revealed either definite or probable exposure to an aerosol containing infectious rickettsiae; in no case was there evidence of parenteral exposure either by accidental self-inoculation or by tick bite. These illnesses are believed to represent RMSF acquired via the respiratory route; this report emphasizes the aerosol hazard of Rickettsia rickettsii in the laboratory and discusses the possibility of respiratory transmission of RMSF in nature. Cell-mediated immunity, as measured by lymphocyte transformation to rickettsial antigen, was detected in these patients and was correlated with serologic studies. (Author)

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Document Details

Document Type
Technical Report
Publication Date
Apr 28, 1977
Accession Number
ADA039504

Entities

People

  • Charles N. Oster
  • Donald S. Burke
  • Michael S. Ascher
  • Philip Harber
  • Richard H. Kenyon

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Blood
  • Cardiovascular Physiological Phenomena
  • Cardiovascular System
  • Cells
  • Health Services
  • Infectious Diseases
  • Leukocytes
  • Medical Personnel
  • Pain
  • Ticks
  • Vaccines

Fields of Study

  • Medicine

Readers

  • Immunology
  • Infectious Disease/Epidemiology
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