Toxicity Studies of Triaminoguanidine Nitrate

Abstract

The acute toxicity of triaminoguanidine nitrate (TAGN) has been studied. The LD(50) of TAGN in mice was 3.65 g/kg with 95% confidence limits of 3.54 - 3.76 g/kg. At IV doses of 50-200 mg/kg given to anesthetized dogs, TAGN caused a slightly decreased heart rate and a transient fall in arterial blood pressure followed by a slight increase. In these animals, TAGN did not alter the function of the peripheral autonomic nervous system or the neuromuscular junction.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 1977
Accession Number
ADA039514

Entities

People

  • C. T. Olson
  • K. C. Back
  • R. N. Terpolilli
  • Richard A. Davis

Organizations

  • Air Force Research Laboratory

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Air Force
  • Animal Structures
  • Animals
  • Autonomic Nervous System
  • Biomedical Research
  • Cardiovascular Physiological Phenomena
  • Governments
  • Hazards
  • Heart Rate
  • Nerves
  • Nervous System
  • Nitrates
  • Peripheral Nervous System
  • Pharmacology
  • Rodents
  • Toxic Hazards
  • Vagus Nerve

Fields of Study

  • Biology
  • Chemistry
  • Medicine

Readers

  • Cardiovascular Physiology
  • Rocket Propulsion.