Reversal of Myocardial Failure in Endotoxin Shock with Insulin.
Abstract
Recent data reported from this laboratory have documented myocardial dysfunction in canine endotoxin shock. The purpose of the present study was to determine the separate effects of insulin and glucose of the failing canine myocardium. Two groups of experiments were conducted on isolated working left ventricular preparations in which LD100 endotoxin was administered prior to, or following, isolation of the heart. Myocardial dysfunction occurred between 2 and 6 hours post-endotoxin. Insulin infusion, at mean rates of 6 units/minute administered via left atrial cannulation, reversed all signs of myocardial failure. During insulin infusion, heart rates decreased (p<0.02) and myocardial lactate uptake increased (p<0.02), while oxygen uptake and coronary blood flow were insignificantly altered. Findings indicate that the positive inotropic effects of insulin occur without additional oxygen requirements.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 08, 1977
- Accession Number
- ADA039524
Entities
People
- Beverly K. Beller
- Jane K. Drake
- Lerner B. Hinshaw
- Linda T. Archer
- Thomas L. Whitsett
Organizations
- University of Oklahoma Health Sciences Center