Final Report to the Office of Naval Research.
Abstract
The spin-label studies of hemoglobin provide many basic examples of how the spin-label technique may be applied to biological systems. It became clear that covalently attached spin labels are extremely sensitive probes when differences between a 'strongly-immobilized' spectrum and one with 'weaker immobilization' were correlated with the function of a biological model. These techniques are now readily applicable to analyses of other isolated proteins. A concerted transition model was developed, that accounts for several biochemical and biophysical functional properties of hemoglobin, and homoglobin mutants. Continued development of spin-label magnetic resonance methods for determination of the rates of very slow molecular motion (molecular motions with correlations in the range of .001 to .0000001 sec) is reported.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 03, 1976
- Accession Number
- ADA039690
Entities
People
- Harden M. Mcconnell
Organizations
- Stanford University