Effects of Endotoxin on Glucose Uptake by the Isolated Forelimb of the Dog.
Abstract
Recent research has demonstrated an increase in glucose utilization by skeletal muscle occurs in hemorrhagic shock. It is conceivable that the hypoglycemia of gram negative septic shock is, in part, due to an increased glucose utilization by peripheral tissues. The hypothesis tested in this study was there is an increase in glucose uptake by the isolated innervated and/or denervated forelimb of the dog subjected to endotoxin shock. Results indicate that endotoxin does not affect a net increase of glucose uptake by the isolated forelimb. No increase in uptake occurred when blood glucose concentration was normal. However, when endotoxin hypotension induced a significant hyperglycemia or when arterial glucose concentration was elevated by glucose administration, an apparent increase in forelimb glucose uptake occurred. It is concluded that endotoxin does not increase the uptake of glucose by skin and muscle except that it causes a hyperglycemia secondary to an increased sympathoadrenal discharge in the shock state. If the dog becomes sufficiently hyperglycemic, an apparent increase in glucose uptake occurs probably because of accumulation of glucose in the interstitial space of skin and muscle.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 11, 1977
- Accession Number
- ADA039701
Entities
People
- M. Jack Keyl
Organizations
- University of Oklahoma Health Sciences Center