The Effect of Vasodilator Drugs (Roniacol and Priscoline) on Skin Temperatures and Blood Flow During Mild Cold Stress.
Abstract
Two vasodilator drugs (Roniacol and Priscoline) were tested for their potential prophylactic effect in the prevention of cold-induced vasoconstriction in the hands of human subjects during exposure to mild cold stress. The drugs were administered as a single dose by mouth (300 mg Roniacol or 50 mg Priscoline) to nude subjects lying quietly for 90 minutes at 21 C. Skin temperatures were measured at the left middle finger, the left big toe and the abdomen, also, skin blood flow in the right middle finger was monitored. Neither Roniacol nor Priscoline had any effect on these measurements of skin temperature or skin blood flow as compared to similar measurements made in control (no drug) exposures. Because of these negative findings in nude subjects during mild cold stress, it is suggested that these drugs would provide no significant protection against cold hands for clothed individuals exposed to a more severe cold stress. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 1977
- Accession Number
- ADA039733
Entities
People
- S. D. Livingstone
- W. S. Myles
Organizations
- DRDC Toronto