Immune Responses in Parasitic Diseases.
Abstract
The effect of Trypanosoma rhodesiense 1886 infection in the rat results in significant stimulation of the IgG1 and IgM immunoglobulin levels. The effect of this parasitic infection on an ongoing antibody response to the hapten DNP was evaluated by immunizing rats with DNP-BGG followed by an infection with T. rhodesiense at a time when antibody production with hapten specificity is ongoing. Potentiation of the IgG1 antibody response to DNP was observed but no potentiation of the IgM response was noted. This would suggest that programmed IgM antibody production was unaffected by the parasitic infection whereas an ongoing antibody response in IgG1 class was modulated by the infection. In a related study, it was demonstrated that rats infected with T. rhodesiense 1886 developed evidence of glomerulonephritis. This is associated with a depressed complement level presumbably due to consumption of complement proteins associated with circulating immune complexes.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1976
- Accession Number
- ADA040243
Entities
People
- Daniel J. Stechschulte
- Herbert B. Lindsley
Organizations
- University of Kansas Medical Center