Effect of Interferon on Togavirus and Arenavirus Infections of Animals

Abstract

The sensitivity of togaviruses to the effects of interferon (IF) appears to permit successful exploitation of IFF inducers, whereas the relative insensitivity of arenaviruses to IF in vitro appears to correlate with the complete lack of success of lysine-stabilized poly(I)-poly(C) - (poly(ICLC)) therapy in the monkey model. Noteworthy is the successful use of poly(ICLC) against fatal encephalitis caused by Japanese encephalitis virus in monkeys. Additional studies appear to be warranted to characterize further the role of IF and/or IF inducers in other model infections prior to studies in man.

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Document Details

Document Type
Technical Report
Publication Date
May 25, 1977
Accession Number
ADA040261

Entities

People

  • Edward L. Stephen
  • Gerald A. Eddy
  • Hilton B. Levy
  • Stephen K. Scott

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animals
  • Arbovirus Infections
  • Arthropod-Borne Encephalitis
  • Biomedical Research
  • Diseases And Disorders
  • Encephalitis
  • Equine Encephalitis
  • Infection
  • Infectious Diseases
  • Interferon
  • Laboratory Animals
  • Plastic Explosives
  • Proteins
  • United States
  • Virus Diseases
  • Viruses
  • Wound Infections

Fields of Study

  • Biology
  • Medicine

Readers

  • Theoretical Analysis.
  • Virology (or Medical Virology).