Host Metabolic Alterations during Venezuelan Equine Encephalitis in the Rat.
Abstract
Use of the V-198 strain of VEE in the rat produces a uniform model in which to study metabolic alterations. Changes that occur early in the disease include viremia, neutrophilia, a decrease in plasma zinc and transferrin and increased amino acid uptake into liver. Plasma zinc depression persists into the later stage of the disease, but to a lesser degree. An increase in plasma copper and seromucoid occurs late in the disease concurrent with the development of pronounced encephalitis. Hypoalbuminemia and decreased ketonemia occur during both the early and late stages of the disease. Taken together, these metabolic alterations chronicle the development of VEE in the rat and thus may be useful as prognostic indicators, in formulating supportive therapy, and as monitors of potential antiviral therapy.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 02, 1977
- Accession Number
- ADA040815
Entities
People
- Alexander Depaoli
- Harold A. Neufeld
- Judith A. Pace
- Michael C. Powanda
- Peter B. Jarhling
Organizations
- United States Army Medical Research Institute of Infectious Diseases