Final Progress Report, 1961-1976,
Abstract
This laboratory has completed its long standing research objective in determining the role of the heart in hemorrhagic or burn shock. Metabolic alterations in the heart during hemorrhagic shock were determined from changes in catecholamines, electrolytes, carbohydrates and enzymes. Myocardial depressant factor was not found to contribute to the terminal shock state. Phenoxybenzamine appeared to have a beneficial effect on renal function by enhancing K+ excretion. Metabolic alterations in burn shock seem to have arisen from coronary insufficiency as determined from changes in catecholamines, histamine, lipids, lipases and LDH activity. A hepatic metabolism study showed that the liver likely plays a major role in the pathogenesis of burn shock. In addition, norepinephrine, prostaglandin E1, and carbachol were used to study changes in myocardial cyclic nucleotides, lipids, lipid turnover and sympathetic-parasympathetic nervous system interaction. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 16, 1977
- Accession Number
- ADA040825
Entities
People
- Vincent V. Glaviano
Organizations
- Chicago Medical School