In Vivo Metabolism of Adrenocortical Steroids: Cerebrospinal Fluid Ions and Neuro-transmitters as Modifiers of the Hypothalamic-Hypophyseal-Adrenocortical System.
Abstract
The present study was designed to investigate whether alterations, within physiological ranges, in the concentrations of various CSF cations (e.g., Na+, K+, Ca2+, Mg2+) could affect the basal activity of the HHA system directly or through their actions on neurotransmitters which are known to modulate the activity of the hypophysiotropic area. Adult male and female cats were prepared with left lateral cerebroventricular and right atrial cannulae. These studies demonstrated that although elevated CSF K+, Ca2+ or Mg2+ did not alter plasma cortisol levels, reducing these CSF cations activated the HHA system, possibly by hyperpolarizing an inhibitory neural path(s) to CRF neurons. Altering CSF Na+ and Li+ did not affect HHA activity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1976
- Accession Number
- ADA041231
Entities
People
- S. F. Marotta
Organizations
- University of Illinois Urbana–Champaign