LD Typing for Bone Marrow Transplantation.

Abstract

The primary goal of this work was to identify homozygous typing cells which could be used in various test systems to identify the tissue typing antigens of the fourth locus of the human histocompatibility system. The following has been accomplished: (1) serological testing for HLA-A,B and C loci revealed a population that appeared to be homozygous for these determinants. (2) Mixed lymphocyte cultures (MLC) were undertaken between these individuals and members of our HLA-D typed panel. (3) Lymphocyte cultures with a panel of known homozygous typing cells enabled the authors to assign specificities to several of the cells collected. (4) A panel of over 60 cells have been typed for all known HLA-A,B and C antigens as well as with homozygous cells to establish D specificities.

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Document Details

Document Type
Technical Report
Publication Date
Jun 15, 1977
Accession Number
ADA041624

Entities

People

  • Paula J. Romano

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • Biological Sciences
  • Biomedical Research
  • Biophysics
  • Bone Marrow
  • Bones
  • California
  • Cells
  • Contracts
  • Identification
  • Lymphocytes
  • Military Research
  • New York
  • North Carolina
  • Scientific Research
  • Security
  • United States
  • Virginia

Fields of Study

  • Biology

Readers

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  • Immunology

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech