Further Evidence of a Possible Central Nervous System Role for Leukocytic Endogenous Mediators (LEM).
Abstract
LEM obtained from glycogen-induced peritoneal exudates in rabbits was injected intracerebroventricularly to determine if the mode of action of LEM was via the monoamines (norepinephrine and serotonin), acetylcholine or prostaglandins. LEM given ivc produced fever, lowered plasma zinc levels and increased plasma alpha(2)- MFP concentrations. LEM, change in LEM and saline injected icv were all observed to have a nonspecific effect on blood neutrophils and lymphocyte concentrations. Pretreatment with atropine, alpha-MPT and p-chlorophenylalanine all failed to modify the zinc depression and fever effects of LEM. However, they did significantly inhibit the synthesis of plasma alpha(2)-MFP. Pretreatment with prostaglandin synthesis inhibitors, indomethacin, acetylsalicylic acid and acetaminophen, increased the latency of the fever without effecting zinc or alpha(2)-MFP. Administration of these prostaglandin synthesis inhibitors during the fever slightly lowered the fever response for approximately 30 min but failed to alter zinc or alpha(2)-MFP.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 08, 1977
- Accession Number
- ADA041948
Entities
People
- Carol A. Mapes
- Edward C. Hauer
- Fred B. Abeles
- Paul T. Bailey
Organizations
- United States Army Medical Research Institute of Infectious Diseases