Activity of Amantadine, Rimantadine and Ribavirin against Swine Influenza in Mice and Squirrel Monkeys.
Abstract
Amantadine, rimantadine, and ribavirin given orally, either prophylactically or therapeutically, reduced mortality and increased the survival time of mice infected with the type A/New Jersey (swine) strain of influenza virus. In addition, amantadine and rimantadine therapy increased the rate of virus clearance from lungs of infected mice. Amantadine treatment initiated either before or after virus challenge ameliorated the illness in squirrel monkeys; when therapeutically-administered it stopped virus shedding from infected monkeys within hours.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 09, 1977
- Accession Number
- ADA041949
Entities
People
- E. L. Stephen
- G. H. Scott
- R. F. Berendt
Organizations
- United States Army Medical Research Institute of Infectious Diseases