The Role of Inflammation in Zinc, Amino Acid and Protein Alterations Induced by Zinc Chloride.
Abstract
The ip injection of zinc chloride (4-16 mg/kg) produces a curvilinear increase in plasma zinc concentration, a linear increase in liver zinc content, and an increase in the hepatic uptake of C(14) aminoisobutyrate which ar significantly greater than control values. This dose range of ZnCl2 also produces neutrophilia, increases in the plasma phenylalanine/tyrosine ratio and seromucoid and the appearance of alpha(2)-macrofetoprotein in the plasma, all of which are indicative of inflammation. It is suggested that some of the protective and metabolic effects ascribed to zinc may in fact be the result, at least in part, the inflammation which occurs when zinc salts are injected ip. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 21, 1977
- Accession Number
- ADA042131
Entities
People
- Edward C. Hauer
- Michael C. Powanda
- Philip Z. Sobocinski
- Richard E. Dinterman
Organizations
- United States Army Medical Research Institute of Infectious Diseases