Effects of Staphylococcal Enterotoxin B on Functional and Biochemical Changes of the Lung in Macaques 1,2,3.
Abstract
A single intravenous (i.v.) injection of staphylococcal enterotoxin B (SEB) in rhesus monkeys at doses of 0.05 to 1.0 mg/kg has been shown to cause hypotension and death within 20 h. It was purposed to study pulmonary functions and arterial blood gas tension, as well as surface tension, water content, and electrolyte concentrations in the lungs of anesthetized normal and SEB-challenged rhesus monkeys. Pulmonary functions did not change during the first 5 h after SEB inoculation. However, during the hypotensive period from 6 to 11 h following SEB injection, respiratory quotient increased, while functional residual capacity, CO2 output, O2 consumption and expired CO2 concentration decreased. By 11.5 h, total lung water content increased, as shown by simultaneous accumulations of extracellular Na+ and water. Conversely, the intracellular lung water and Na+ decreased. Further, the surface tension of lung extracts increased.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1977
- Accession Number
- ADA042193
Entities
People
- C. L. Hadick
- C. T. Liu
- M. J. Griffin
- R. D. Delauter
Organizations
- United States Army Medical Research Institute of Infectious Diseases