Studies on Typhus and Spotted Fever.

Abstract

Methodology has been developed for detection of antibiotic resistant mutants of R. prowazeki, determination of mutant frequencies and possibly mutation rates. A mouse test for virulence of R. prowazeki has been refined. Search for transformants resulting from selective intracellular release of DNA is in progress. Growth characteristics of R. mooseri differ from those of R. prowazeki. Fifteen strains, 8 established species and 7 field isolates, of spotted fever group rickettsiae have been subjected to intensive morphological, biological, and serological study. Certain properties are held in common by most of the strains (slime layer, type 2 growth cycle, large plaque size, doxycycline sensitivity, penicillin-induced spheroplast formation) whereas serological characteristics appear to segregate the strains into species and sub-groups of related strains.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 1977
Accession Number
ADA042321

Entities

People

  • Charles L. Wisseman Jr.

Organizations

  • University of Maryland, Baltimore

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animal Structures
  • Anti-Bacterial Agents
  • Blood
  • Body Fluids
  • Cell Membrane
  • Cells
  • Cells (Biology)
  • Cellular Structures
  • Culture Techniques
  • Immune Serums
  • Infection
  • Intact Stability
  • Medical Personnel
  • Membranes
  • Resistance
  • Rodents
  • Wound Infections

Fields of Study

  • Biology

Readers

  • Computational Modeling and Simulation
  • Microbial Pathology
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