Topical Hazard Evaluation Program of Candidate Insect Repellent AI3-36080 Lactone of Dihydrosasome.

Abstract

A hazard evaluation of AI3-36080 was conducted using New Zealand White rabbits for skin and eye studies; Hartley guinea pigs for a skin sensitization study; and Sprague-Dawley, Wistar-derived rats for acute oral toxicity. The candidate compound produced no skin or eye irritation, no photochemical irritation, no sensitization reaction and did not demonstrate an acute ingestion hazard. Ethanol solutions of AI3-36080 caused mild skin irritation to both UV and non-UV irradiated skin sites. Based on these findings, it is recommended that AI3-36080 be approved for further testing as a candidate topical insect repellent.

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Document Details

Document Type
Technical Report
Publication Date
Aug 03, 1977
Accession Number
ADA042595

Entities

People

  • Brenda J. Desena
  • Maurice H. Weeks

Organizations

  • United States Army Medical Command

Tags

DTIC Thesaurus Topics

  • Alcohols
  • Animals
  • Health
  • Health Services
  • Insect Repellents
  • Irritation
  • Laboratory Animals
  • Lagomorphs
  • New Zealand
  • Pest Control
  • Physical Properties
  • Rodents
  • Security
  • Test And Evaluation
  • Toxicity

Fields of Study

  • Medicine

Readers

  • Toxicology/Environmental Toxicology