Inhibition of the Ethanol-Induced Presynaptic Release of Acetylcholine by Hemicholinium-3,
Abstract
Various concentrations of ethanol (0.29 - 1.09 M) potentiated the indirect supramaximal twitch in the rat diaphragm (RD) and chick biventer cervicis (CBC) preparations. Ethanol (1.09M) produced a contraction of the muscle. Ethanol (0.43 M - 0.72 M) was found to antagonize the curare neuromuscular (NM) blockade but not the hemicholinium-3 (HC-3) blockade in both preparations. However, if ethanol was applied after washout of HC-3 a potentiation of the twitch response was noted. Pretreatment of the RD for various times with various concentrations of ethanol was found to protect against curare but not HC-3 NM blockade. Tetraethylammonium produced results similar to ethanol in that it antagonized the curare blockade but not the HC-3 NM blockade on the CBC and RD preparations.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1977
- Accession Number
- ADA042718
Entities
People
- John G. Clement
Organizations
- Defence Research and Development Canada