Gonococcal Subgroups: Identification, Isolation and Physicochemical Characterization of Gonococcal Subgroup Antigens.
Abstract
This final progress report gives the details of studies into the development of a gonococcal serogrouping system based on a family of acidic polysaccharides isolated from gonococcal phenol water extract by DEAE chromatography. Initially, two antigenically distinct populations of gonococci were identified and designated Gc1 and Gc2. During the course of this study, two additional serogroup antigens designated Gc3 and Gc4 have been identified and isolated. All serogroup antigens share common core structures which are identifiable immunologically. An HAI system has been developed which can be used to detect the presence of these serogroup antigens on clinically isolated gonococci. Organisms are prepared for analysis by production of an extract which is standardized by their nucleic acid content. One hundred and sixty-three clinically isolated gonococci were studied in this HAI system and seven populations have been identified.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 31, 1976
- Accession Number
- ADA042835
Entities
People
- James C. Allen
- Michael A. Apicella
Organizations
- State University of New York at Albany