Biochemical Analysis of Cerebrospinal Fluid in Response to Drug Administration.
Abstract
Using dogs, it was found that d-amphetamine (3 mg/kg i.v.) produces a threefold increase in CSF levels of the norepinephrine metabolite MHPG. L-amphetamine at the same dosage level produced either no change in MHPG or had a relatively smaller effect. Cerebral blood flow increased threefold with d-amphetamine at 3 mg/kg in dogs, and only slightly after the 1-isomer at the same dose. Arterial pressure doubled after d-amphetamine (3 mg/kg) and only increased 20-30% after the 1-isomer at the same dose. A close correlation between arterial pressure, brain blood flow and CSF production rate was observed for d-amphetamine. The d-isomer also resulted in pronounced myocardial effects at 3 mg/kg, whereas the 1-isomer did not. The myocardial effects consisted of multiple ventricular foci on the ECG, and were not observed with the 1-isomer. Some PVC's were observed with the 1-isomer. The effect of the d-isomer on cerebral blood flow was shown to be due to a direct action and was not related to the pressor effects. The d-isomer at 3 mg/kg also decreased the permeability of the blood-brain barrier to Chloride during ventriculo-cisternal perfusions in the dogs. In Primate studies the authors have shown diurnal variations in the CSF production rate and CSF levels of MHPG.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 07, 1974
- Accession Number
- ADA042845
Entities
People
- Barry Burns
Organizations
- Johns Hopkins University