On the Cross-Reactivity of Staphylococcal Enterotoxins A, B, and C,
Abstract
Strong cross-reactions were demonstrated for staphylococcal enterotoxin B (SEB) and C1 (SEC1) by antigen-binding capacity and by competitive binding ability. Both SEB and SEC1 combined completely with the heterologous antibody although requiring four times as much antiserum as the homologous enterotoxin and both displaced about one-third of the other enterotoxin from a heterologous antigen-antibody system. It is proposed that one of the three major antigenic determinants of these enterotoxins possesses a significant similarity but probably not an identity of structure. SEB and SEC1 did not combine with antiserum to entertoxin A nor inhibit the reaction of SEA with anti-SEA. SEA had no intrinsic binding capacity for anti-SEB or antiSEC1 nor did it inhibit the binding of either enterotoxin to its own antibody.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1977
- Accession Number
- ADA043443
Entities
People
- Beverly Morlock
- Joseph F. Metzger
- Leonard Spero
Organizations
- United States Army Medical Research Institute of Infectious Diseases