In Vitro and In Vivo Actions of Zinc Ion Affecting Cellular Substances which Influence Host Metabolic Responses to Inflammation.

Abstract

Glycogen-stimulated rabbit peritoneal exudate cells (polymorphonuclear leukocytes, PMN) product prostaglandins (PG) and substances which induce alterations (mediators) in experimental animals characteristic of host metabolic responses to infection and other acute inflammatory stresses. The effect of Zn2+ on mediator production and PG synthesis was examined. Using exudate cells, 2 mM Zn2+ caused complete inhibition of in vitro PG synthesis as assessed by conversion of (1-14C) arachidonic acid into PG. This concentration of Zn2+ also inhibited production of substances mediating plasma Zn depression, hepatic amino acid 'uptake', fever, and neutrophil release from bone marrow. Conversely, Zn2+ did not inhibit in vivo metabolic responses to these mediators. Zn-pretreatment of rabbits or simultaneous injection of Zn2+ and crude PMN-derived pyrogenic activity resulted in prolongation of fever.

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Document Details

Document Type
Technical Report
Publication Date
Jul 06, 1977
Accession Number
ADA043553

Entities

People

  • Carol A. Mapes
  • Charles F. Matson
  • Edward C. Hauer
  • Paul T. Bailey
  • Philip Z. Sobocinski

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Amino Acids
  • Biomedical Research
  • Blood
  • Blood Cells
  • Body Temperature
  • Bone Marrow
  • Cardiovascular System
  • Cells
  • Chemistry
  • Defense Mechanisms
  • Granulocytes
  • Incubation
  • Laboratory Animals
  • Leukocytes
  • Lymphocytes
  • Polymorphonuclear Leukocytes
  • Prostaglandin

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology and Pathology
  • Materials Science and Engineering.
  • Molecular and Cellular Biochemistry