Venezuelan Equine Encephalomyelitis: Protective and Toxic Effects of a Nuclease-Resistant Derivative of Poly(I)-Poly(C).

Abstract

Polyriboinosinic-polyribocytidylic acid stabilized with poly-1-lysine and carboxymethylcellulose, poly (ICLC), favorably alters the pathogenesis of Venezuelan equine encephalomyelitis infection in rhesus monkeys by decreasing the number of monkeys that become detectably viremic and by delaying the onset of viremia in the remaining monkeys. Poly(ICLC) is known to induce high, circulating levels of interferon in primates and the interferon system is assumed to be the mechanism by which poly(ICLC) exerts its antiviral activity. Poly-(ICLC) treatment was associated with mortality only under certain conditions of infection and handling. The death of some infected-treated monkeys in the absence of death in monkeys that were either infected and untreated or treated and uninfected suggests a synergistic toxicity resulting from the combination of infection, handling and poly(ICLC) treatment.

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Document Details

Document Type
Technical Report
Publication Date
Aug 17, 1977
Accession Number
ADA043554

Entities

People

  • Duane E. Hilmas
  • Edward L. Stephen
  • Hilton B. Levy
  • Richard O. Spertzel

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animals
  • Antibodies
  • Arbovirus Infections
  • Biomedical Research
  • Catheters
  • Diseases And Disorders
  • Infection
  • Infectious Diseases
  • Interferon
  • Laboratory Animals
  • Proteins
  • Rhesus Monkeys
  • Venezuelan Equine Encephalomyelitis
  • Virus Diseases
  • Viruses
  • Wound Infections
  • Yellow Fever

Fields of Study

  • Biology
  • Medicine

Readers

  • Toxicology/Environmental Toxicology
  • Virology (or Medical Virology).